^ Jump up to: a b c Malenka RC, Nestler EJ, Hyman SE (2009). "Chapter 15: Reinforcement and Addictive Disorders". In Sydor A, Brown RY. Molecular Neuropharmacology: A Foundation for Clinical Neuroscience (2nd ed.). New York: McGraw-Hill Medical. pp. 364–368. ISBN 9780071481274. The defining feature of addiction is compulsive, out-of-control drug use, despite negative consequences. ...
Many treatment plans begin with a detoxification program to help break your body’s physical addiction to alcohol. Detoxification is often performed in an inpatient therapy treatment center or hospital. It typically takes one week to complete. Because the symptoms of physical withdrawal can be dramatic, you may also be given medications to help prevent: Overview of Medical Detox from the Best Drug Rehab Centers (888) 598-0909
According to the National Institute on Drug Abuse, addiction is a "chronic, relapsing brain disease that is characterized by compulsive drug seeking and use, despite harmful consequences."7  There is no simple cure for addiction; however, effective treatment can help you become and stay sober.7  You will have to manage your addiction throughout your life, the same way a diabetic has to manage their condition with ongoing efforts like a proper diet and exercise.8 Drug Rehab Near Me
^ Blum K, Werner T, Carnes S, Carnes P, Bowirrat A, Giordano J, Oscar-Berman M, Gold M (2012). "Sex, drugs, and rock 'n' roll: hypothesizing common mesolimbic activation as a function of reward gene polymorphisms". Journal of Psychoactive Drugs. 44 (1): 38–55. doi:10.1080/02791072.2012.662112. PMC 4040958. PMID 22641964. It has been found that deltaFosB gene in the NAc is critical for reinforcing effects of sexual reward. Pitchers and colleagues (2010) reported that sexual experience was shown to cause DeltaFosB accumulation in several limbic brain regions including the NAc, medial pre-frontal cortex, VTA, caudate, and putamen, but not the medial preoptic nucleus. Next, the induction of c-Fos, a downstream (repressed) target of DeltaFosB, was measured in sexually experienced and naive animals. The number of mating-induced c-Fos-IR cells was significantly decreased in sexually experienced animals compared to sexually naive controls. Finally, DeltaFosB levels and its activity in the NAc were manipulated using viral-mediated gene transfer to study its potential role in mediating sexual experience and experience-induced facilitation of sexual performance. Animals with DeltaFosB overexpression displayed enhanced facilitation of sexual performance with sexual experience relative to controls. In contrast, the expression of DeltaJunD, a dominant-negative binding partner of DeltaFosB, attenuated sexual experience-induced facilitation of sexual performance, and stunted long-term maintenance of facilitation compared to DeltaFosB overexpressing group. Together, these findings support a critical role for DeltaFosB expression in the NAc in the reinforcing effects of sexual behavior and sexual experience-induced facilitation of sexual performance. ... both drug addiction and sexual addiction represent pathological forms of neuroplasticity along with the emergence of aberrant behaviors involving a cascade of neurochemical changes mainly in the brain's rewarding circuitry.

It is well known that our body and appearance change the older we get, but most do not realise that the way in which alcohol is broken down and processed slows with age. According to the Royal College of Psychiatrists, the recommended alcohol guideline amounts of fourteen units per week should probably be lower for older adults to take account of these changes.
Any drug overdose can be either accidental or intentional. Drug overdoses are the leading cause of death for Americans under 50. Accidental overdoses tend to happen when people take more of a prescription medication than originally intended to achieve certain results, or when they use too much of an illegal drug trying to get a better high. Intentional overdoses are usually a result of someone trying to commit suicide. Regardless of the intent, any loss of life due to an overdose is tragic and any overdose can have severe and lasting repercussions.
Stimulants, such as tobacco, cocaine or prescription amphetamines, stimulate the brain and nervous system, causing increased alertness. Depressants, such as barbiturates and benzodiazepines, slow activity in the brain and nervous system, causing relaxation. Hallucinogens, such as LSD and PCP, drastically disrupt the way the brain and nervous system communicate, causing hallucinations. Rehab: Last Week Tonight with John Oliver (HBO)
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